July 15, 2022

Adsorption Isotherm Models for Chromatography





In order to create a complete chromatography model, the adsorption of components within the adsorber beads needs to be considered. In this article we discuss adsorption models for ion exchange, hydrophobic interaction, and mixed-mode chromatography.

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Tags: mechanistic modeling, chromatography, downstream, protein purification, Process development; QbD; Design of experiments