Lentiviruses are commonly used for both chimeric antigen receptor (CAR) T cell therapy and ex vivo gene therapy.
Vector purification is very challenging due to low stability of these enveloped viruses, which are sensitive to low pH, high salt, temperature, shear forces, and other factors.
To maximize physical and infectious titer, it’s important to carefully tune the conditions of each downstream step with these sensitivities in mind.
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