Fiber-based matrices for affinity purification is suitable for rapid-cycling chromatography. Fiber chromatography matrices such as Fibro PrismA can bind a large amount of protein in a fraction of the purification time required for an affinity resin. Just like with resins, the dynamic binding capacity (DBC) of a Fibro unit is affected by process conditions and by the properties of the target molecule. Thus, determining the DBC of a Fibro unit is still a key step in your process.