Large volume single-use technology mixers can be used for mixing operations throughout the entire bioprocess workflow. Large-volume mixers are mainly required in clinical three-scale and production-scale facilities where mixing efficiency is one of the key drivers of throughput efficiency. Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mixing.
Dispersion and settling were evaluated as part of this study, which provides a clear decision path on the tank shape and impeller quantity for a given impeller design and a given impeller location. Dissolution studies will be used in the future to understand the liquid-liquid and powder-liquid mixing times along with zone mapping and test validation.
September 29, 2016