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In this webinar, we will describe and evaluate different process intensification strategies for the monoclonal antibody (mAb) capture step. Strategies will depend on the mode of upstream operations (fed batch or perfusion) and the desired process improvement of the capture step, (e.g., productivity, cost, or process time) as well as the type of manufacturing scenario (clinical or commercial).
We will discuss opportunities with the introduction of high-capacity protein A resins, how and when multicolumn chromatography is beneficial, and how emerging technologies such as rapid cycling Fibro chromatography can address bottlenecks.
In this webinar you will learn:
• Strategies and emerging technologies for intensifying the mAb capture step
• How the design of your upstream mode may determine your optimal downstream solution
• When technologies like rapid cycling chromatography are competitive alternatives for the protein A step.