Search results for " monoclonal" in Articles / App Notes
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eBook: Purification of Antibody Therapeutics - Approach for Diversified Pipeline
Over the years, development beyond traditional monoclonal antibodies (mAbs) has increased. Today, we see multispecific and bispecific antibodies, antibody fragments, and antibody drug conjugates in th…
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Optimizing your Cell Culture Process to Improve Productivity
It could also be used to analyze monoclonal antibody protein quality by examining the parameters, supplements, and feed timings, which may help increase the quality of the protein being produced in cu…
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What’s in your media? How costly is variability of cell culture media to your manufacturing process?
There have been numerous studies which have been done looking at trace metal effects on monoclonal antibodies. Some of the studies performed investigated the glycosylation patterns. For example, the s…
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Get to know: mAb variants - eLearning
Cytiva has published an interactive course that gives an overview of monoclonal antibodies (mAbs) and current variants used and developed in academia and industry.
Key learnings are:
- Structure…
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Enhancing Resins Addresses Purification Concerns
There are, however, similarities in certain classes of biologics, such as monoclonal antibodies. “Because traditional monoclonal immunoglobulin G (IgG) products share a similar structural and chemical…
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FDA Provides Guidance on Bispecific Antibody Development Programs
Of note, many aspects of a bispecific antibody development program will be similar to monoclonal antibody development programs. This guidance discusses unique aspects for chemistry, manufacturing, and…
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Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
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In clinical monoclonal antibody (mAb) manufacturing, capture on protein A chromatography resin gives excellent recovery and purity. However, because clinical batch siz…
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A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
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Cytiva Advances Fiber Chromatography Technology with New Launch
27, 2021, Cytiva announced the launch of HiScreen Fibro PrismA, the newest product available for early monoclonal antibody (mAb) purification process development. The product complements HiTrap Fibro …
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Updating Viral Clearance for New Biologic Modalities
…extracellular debris, they require meticulous filtration, even in more established processes such as monoclonal antibody production.
However, demonstrating viral clearance is even more difficult …