Search results for " production" in Articles / App Notes
Article
Stirring up the fermentation game
Bioreactors designed for production in mammalian culture fall short of meeting these unique requirements, for example in terms of oxygen transfer capacity and temperature control. The Xcellerex XDR-50…
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Under pressure: exploring root causes of leaks in single-use mixers
Single-use technology offers huge benefits for both flexibility and efficiency. It reduces downtime by eliminating cleaning steps, helps avoid risk of cross-contamination, and enables modulari…
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Quality Considerations for Using AI in Bio/Pharma
The use of artificial intelligence (AI) is seeing a surge in a variety of industries. But does the regulated nature of bio/pharmaceutical development, manufacturing, and commercialization ser…
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Considerations in depth filter scale-up
Depth filters are widely used in the biopharmaceutical industry. They are typically made of a mixture of cellulose, filter aids, and a binder. These components can be milled and mixed in diffe…
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Impurity ELISA automation for faster process development
Host cell proteins (HCPs) produced by cells during biologic manufacturing must be removed from the final product to protect patients. However, it’s challenging to detect HCP, and this step can…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
We demonstrate a scalable workflow for the isolation of exosomes—a type of extracellular vesicle with significant potential for targeted drug/gene delivery. For research and development and di…
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Video: The solution to smarter column packing
Packing modern chromatography resins at large scale requires a column capable of axial compression to ensure stable, reproducible packed beds. AxiChrom™ columns are low-pressure, axial compressi…
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Discovering the unknown: How does in silico process development change PD scientists’ work?
In silico process development for chromatography is a paradigm-shifting approach that redefines the routine work of process development scientists. But what does it actually mean to perfor…
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A scalable single-use two-step plasmid purification process
While MAb processes have become much more efficient, production of mRNA and viral vectors is still hindered by the requirement for a reliable source of high-quality plasmid DNA (pDNA), which typically…
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Report from the 6th International HTPD Conference
The biggest challenge is still the people and Quantitative Structure-Activity Relationship (QSAR) plus mechanistic modeling were two key take-home messages from the 6th International conference devote…