Search results for " surfac"
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Next Generation Process Chromatography
The surface area that Fibro exhibits provides immediate binding opportunities at high capacities of the target proteins such as mAbs. This means that a chromatographic cycle that currently takes ~3 ho…
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Gene Therapies Push Viral Vector Production
Infectivity, he explains, is usually dictated by the envelope proteins present in a virus and the cellular surface components to which those proteins bind. “Depending on the application, the ideal vec…
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New Therapies Present Scaling Challenges
In the roller bottle process, cells grow and attach to the surface of cylindrical bottles and are bathed in growth media as the bottle is rolled on a rack inside a temperature-controlled chamber. To i…
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Moving PAT from Concept to Reality
…n evaluation; next-generation sequencing (NGS) for viral and microbial contamination quantification; surface plasmon resonance, amplified luminescent proximity homogeneous assay, and fluorescence res…
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Faster Flavivirus Vaccine Production
Viral vaccines need to be produced fast and in large quantities. Routine immunizations and preventive campaigns, like stockpiling in response to emergencies, involve millions of doses, and speed is es…
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Webinar On-Demand: Novel Analytics to Improve Bioprocessing and Validation Guideline
He also covered the latest regulatory strategies and a new assay validation guideline for surface plasmon resonance (SPR) technology.
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Leveraging Computational Models of Glycosylation for Biopharma QA
Examples of statistical models of TGP glycosylation are design of experiment (DoE) surface response models (23) and partial least squares regression (33,34). Advantages of statistical models are that …
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Are You in Control of the Quality of Your mAbs?
Stuart Knowling from Antibody Analytics presented how the latest innovation in surface plasmon resonance (SPR) technology has been adopted to develop and qualify assays for monoclonal antibodies (mAbs…
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Sensitive and Reproducible SPR-Based Concentration and Ligand-Binding Analyses
Surface plasmon resonance (SPR) assays are used across the life cycle of a biopharmaceutical, from target identification, through CQA determination, development, and on-going quality control. This art…
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Nurturing Knowledge from Disparate Data Streams
Similarly, the volume of data generated in NMR and surface plasmon resonance analyses can be challenging to manage.
Issues with data abstraction
Another challenge given the volume and c…