Search results for " recombinant" in Articles / App Notes
Article
Scalable Viral Vector Manufacturing
Viruses are much larger than recombinant proteins and antibodies, and therefore tailored purification technologies must be used. The scalability factor must be considered as well. We strongly recommen…
Article
Scaling Up Novel Therapies
In addition, he says, it will speed up and allow for screening of a much larger number of variants for mAbs, bispecifics, trispecfics, fragments, and recombinant proteins. For some cell therapies, the…
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A Look into the Future of Biopharmaceutical Quality
…L): Over the past 50 years, the industry has grown, especially due to advances in areas such as recombinant DNA and hybridoma technology, and more recently gene and cell therapies. As these advanceme…
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Industry Adoption of Single-Use Systems Remains Low
Abzena, a CDMO, conducts development and GMP manufacture of antibody drug conjugates at its Bristol facility and conducts development and GMP manufacture of monoclonal antibodies and other recombinant…
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Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants
The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Luminal payloads can be introduced through endogenous loading by recombinant cell lines or through ex vivo loading. One can move to the next level of sophistication by changing the surface of the exos…
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QbD Improves Cell-Culture Process Control
QbD Improves Cell-Culture Process Control
A quality-by-design approach that implements PAT offers advantages in upstream cell-culture processing.
By Feliza Mirasol
Mar…
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Roadmap Leads to Innovative Biomanufacturing Strategies
The initial emphasis of the Biomanufacturing Technology Roadmap has been on the manufacture of recombinant proteins and, even more specifically, on monoclonal antibodies (mAbs).
With successive …
Article
Reducing Cross-Contamination Risks in Process Chromatography
Preferred target molecules
A variety of biologics benefit from the use of disposable technology in their production, from monoclonal antibodies (mAbs) and recombinant medicines to vaccines and…
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ADC Development Robust Despite Lackluster Performance
With nigrin, the company has developed two payloads: a nigrin b-A chain molecule and a recombinant version of the nigrin b-A chain. Nigrin b is a plant toxin derived from the bark of an elder plant (S…