Search results for "single-use" in Articles / App Notes
Article
Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
Cytiva will provide its FlexFactory, a flexible, single-use platform, to enable Akron Biotech to manufacture plasmid DNA (pDNA), which is used in many innovative therapies and vaccines, Cytiva said in…
Article
Simplifying Cell Culture Expansion
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Controlled perfusion in a closed, single-use bioreactor can cut the complexity from your cell culture expansion process, making it possible to go from seed trai…
Article
Scaling a mAb Production Process to Xcellerex Bioreactors
This article discusses moving a monoclonal antibody (mAb) production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Next Generation Process Chromatography
The platform is also compatible with existing installed infrastructure and can fully benefit from single-use operations where this is desired.
Bioprocess Development Forum: Can you shortly describ…
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Eliminating Residual Impurities Starts with a Strategic Plan
They can be derived from the host cell or the product itself, media components, surfactants, virus inactivation agents, inorganic or organic contaminants from permanent and single-use process equipmen…
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New Therapies Present Scaling Challenges
It is estimated that scale-up manufacturing solutions for cell therapies will need to generate batches of up to 2000 L (3) of product using single-use, disposable technology. Dependence on single-use …
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Monitoring and Control of Inline Dilution Processes
“The advent of buffer concentrates delivered in single-use (SU) bags combined with automated, compact precision dilution and blending technology allows these tank farms to be repurposed for more produ…
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Process Economic Simulation for Scalable Production of Adenovirus
The novel process was compared with a reference process in both stainless-steel and single-use configurations across various production scales and scenarios. The process, based on modern tools and tec…
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Challenges in Cell Harvesting Prompt Enhancements
Challenges in Cell Harvesting Prompt Enhancements
Higher cell titers and cell densities have posed a challenge to cell harvesting, a crucial step in biologics manufacturing.
By Feliza Mi…
Article
Automation Trend in Fill/Finish Reduces Contamination Risk
… that use tool-less changeovers, in-process weight checks, self-adjusting fill volume controls, and single-use equipment/technology (4).
Fill/finish operations for biologics is largely automated a…