Search results for "single-use" in Articles / App Notes

Article Improving Upstream Predictability
Single-use bioreactors at commercial scale (i.e., 2000 L) have become standard, he notes. Efforts have been underway for a few years to better integrate upstream and downstream operations to…

Article Flexible Facilities for Viral Vector Manufacturing
The facilities use single-use systems. Murphy says the primary benefit for single-use systems is eliminating the need to perform cleaning validation on reused product contact equipment. References…

Article Making the Move to Continuous Chromatography
Some systems come with flow paths that are designed to be cleaned and reused, while others are flow paths that are single-use. Some systems come with dynamic control functionality—process analytical t…

Article Lessons Learned Accelerate Vaccine Development
High-throughput and single-use technologies are also being leveraged to accelerate key aspects of manufacturing processes, such as determination of appropriate media, resins for purification, formulat…

Article CMOs Continue to Improve Overall Biomanufacturing Performance
CMOs’ love affair with single-use devices has been well documented. Indeed, single-use implementation and integration is a much larger focus for CMOs than it is for biotherapeutic developers. And as t…

Article Tools and Processes for Mature and Emerging Therapies
…s for upstream and downstream systems, and introduced equipment, supplies, columns, media, buffers, single-use systems, and ancillary equipment to promote process capabilities and reliability. Ne…

Article The Outlook for CMO Outsourcing in 2019
The industry is starting to see a major trend for CMOs adding 1000–2000-L single-use bioreactor process lines for commercial manufacturing as products currently in development manufactured with single…

Article Scaling Up Novel Therapies
Cell culture improvements were followed closely by small-scale single-use technologies. As a result, on the bacterial side, developers can now go into production using 100- to 300-L single-use reactor…

Article Optimizing Late-Stage and Commercial Cell-Culture Processes
In addition, development of intensified processes and integrated continuous processing (with single-use technology and sensors/control) have also contributed to increasing titers, maintaining consiste…

Article Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Also unpredicted 15 years ago was the rate of adoption of single-use devices. While 15 years may seem a long adoption cycle, in the bioprocessing industry, where regulators are involved in most decisi…

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