Search results for "modeling" in Articles / App Notes
Article
Good Modeling Practice
However, the main drawback of mechanistic modeling is the cumbersome approach to model calibration. Multicomponent feed stocks lead to multidimensional parameter estimation problems with many unknown …
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Download your Mechanistic Modeling eBook
Mechanistic modeling is a mathematical representation of the physiochemical transport and interactions that occur during chromatography. For example, this methodology uses differential equations that …
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See a chromatography modeling software in action
The typical mechanistic chromatography modeling workflow is an interplay of the tools that you currently use in the lab and the modeling software (Fig 2).
Fig 1. Mechanistic modeling creates…
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Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Ottens reviewed how knowledge-based chromatographic process development based on mechanistic modeling will become more important and more utilized in the industry in the coming years. He also emphasiz…
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Rethinking ion exchange chromatography modeling
In the early days of modeling, mechanistic models for ion exchange chromatography were mostly based on stoichiometric equations. A new adsorption isotherm class was introduced in 2021: the co…
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FAQ: Scale-up and scale-down with mechanistic modeling
… the correct scale for model calibration, and understand how scale-up integrates into a mechanistic modeling workflow.
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Utilization of Mechanistic Modeling to Improve Process Development
Utilization of mechanistic modeling of unit operations, based on scientific and physical understanding of the process, is one of these approaches. Improved computational resources in the past decade h…
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Good modeling practice: workflow and case study
The workflow is illustrated with examples from a modeling case study and provides you with tips and insights for good mechanistic modeling practice.
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Mechanistic modeling quiz: Test your knowledge
How well do you know mechanistic chromatography modeling?
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Adsorption isotherm models for chromatography
Read on commonly used models for the thermodynamics of adsorption within a chromatography column.
Indeed, in order to create a complete chromatography model, the adsorption of compon…