Search results for " control"
Article
Concentration and Buffer Exchange Using the Automated, Single-Use ÄKTA™ readyflux System
The process was conducted in an automated manner based on methods created using phases predefined in the UNICORN™ system control software. Concentration of 5 g/L bovine serum albumin (BSA) was perfor…
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Platform Technologies Improve Protein Expression
They are also expected to speed up the development of novel specific molecules based on the use of chemistry, manufacturing, and controls (CMC) standards and by leveraging capabilities and capacities,…
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Tips for Successful Immunoprecipitation
For immunoprecipitation (IP), there are four main components that you can control to get good results: protocol, resin, format, and antibody. Read these tips to get it right from the start.
Ac…
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Will My Buffers Work When Using an Inline Conditioning System?
Feedback control of the preparation process ensures accurate formulation of the final buffer, and the automation enables high consistency between batches. Compared with traditional buffer preparation,…
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Best Practices for Data Integrity
With an electronic system, you get real-time verification of operator data entry, instead of catching mistakes/missed entry in the final quality control review. Operators receive immediate feedback if…
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Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
…rectly to the Inline Conditioning system and feedback regulation of the final buffers, using dynamic control, ensured accurate formulations.
Read More in the Application Note
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The New World of Biopharmaceutical Manufacturing
Industry experts discuss the single-use revolution and changes to upstream and downstream processing equipment.
By Jennifer Markarian
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N-Glycan Analysis of Biotherapeutic Proteins
Future directions in N-glycan analysis
As glycosylation is a frequently monitored CQA of biotherapeutics, there will likely be increasing regulatory pressure to control processes for better …
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Fusion Proteins Pose Manufacturability Challenges
“In particular, the level of N-acetylneuraminic acid or sialylation, which can impact plasma half-life and the potency of the candidate, is a key quality attribute and can be challenging to control wi…
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Witnessing Major Growth in Next-Generation Antibodies
…ts with novel formats, according to John Joly, senior director of analytical development and quality control with Genentech. He adds that formats have been engineered to engage T cells directly throu…