Search results for "Workflow" in Articles / App Notes
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
HOLISTIC VIEW OF SAMPLE ANALYSIS FOR PROTEIN CHARACTERIZATION
A generalized sample analysis workflow is shown in Figure 1. Typically, protein samples are submitted, prepared, and analyzed, and …
Article
Exosome isolation by tangential flow filtration and size exclusion chromatography
We describe an evaluation of purification workflows from three different cell culture supernatants. The workflows we describe are suitable for scale-up and combine tangential flow filtration (TFF) for…
Article
Top Process Development Trends for 2021 and a Look into 2022
However, the focus in 2021 shifted beyond the pandemic to optimization and scaling up adeno-associated virus (AAV) production, process workflows and considerations for messenger RNA (mRNA) therapeutic…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
Workflows, capital and operating expenses, product quality, and waste production can all be positively impacted by the efficiency gains possible with process intensification.
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The Need for Advanced Process Modeling for New Therapeutic Biologics
As bioprocessing workflows increasingly shift toward automation, the approach to modeling also needs to evolve to incorporate next-generation tools and software. For example, how would process modelin…
Article
Scaling Up Novel Therapies
During initial workflow development, for example, the need to produce material as quickly as possible can override the need to focus on optimizing process simplicity, reliability, and cost-effectivene…
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Single-use Bioreactors Have Reached the Big Time
“When considering the workflow and objectives of running bioreactors, recent developments have focused on reducing complexity, improving mixing to achieve higher volumetric mass transfer coefficients …
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Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Selecting process technologies
The next step is to drill down into the discrete unit operations of the biomanufacturing workflow. If the production process is already defined, it should be listed ou…
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
With HTPD, the typical workflow follows a series of steps, including planning an experimental setup using a systematic approach, carrying out experiments by testing various experimental conditions in …
Article
Automated Concentration and Diafiltration of Multiple siRNA Samples
To effectively screen potential targets for in vivo activity, it is necessary to create an optimized workflow at the appropriate scale, capable of delivering 100 unique siRNA duplex targets per month.…