Search results for " throughput"
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High-Throughput Process Development in Biopharma
Efficient development of the manufacturing process is a crucial component of overall biopharmaceutical development. During early process development, high-throughput process development (HTPD):
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Improving Upstream Predictability
Where, in the past, companies sought biochemists with basic cell culture and purification knowledge, they now require bioengineers with high throughput and automation expertise, says Mohindra. Most ma…
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Mapping a Route for Cell and Gene Therapy Process Development
This approach can potentially enhance process and product standardization, provide effective tracking of processes and in-process controls, and lead to higher throughput and simpler processes,” Lampro…
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Best Practices for Selecting a Top-Quality Cell Line
If the secretory system cannot handle the secretory throughput, the biotherapeutic proteins can become misfolded or have improper secondary modifications,” he explains.
This issue is particular…
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Free On-Demand Webinar: Smart Process Development of Chromatography Steps
Smarter development of chromatography processes reduces timelines and improves outcomes.
Smart process development is a collection of approaches to improve and speed up process development—prov…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
We try to optimize the capital cost for our customers and for us by maximizing the throughput and flexibility of the facility,” he adds.
In addition to current processing needs, Vanek notes that…
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Fiber-Based Protein A Chromatography for HTPD
Developing a process or looking for a clone of interest often requires screening large numbers of samples. Many analyses require purified proteins, and often substantial hands-on time is required fo…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
“Single-use mixers, coupled with single-use bioprocess containers (BPC), can increase a DSP suite’s annual throughput, because they offer turnaround times of around a day or less without the need for …
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An Analytical Approach to Biosimilar Drug Development
Automation has been key in allowing ligand-binding assays to meet the intense throughput and turnaround requirements of biosimilar studies.
References
1. J. Yuan, W.W. Xu, and H.F. P…
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Advances in Engineering of Protein-Based APIs
Cell-free protein synthesis is also promising, but at this point is limited by the current capabilities in gene synthesis, which serves as a bottleneck for throughput. “Low cost, rapid, and precise ge…