Search results for "bioreactor"
Article
Being Thorough When Transferring Technology
For example, when single-use bioreactors were a nascent technology to the industry, there were reports that some bags melted on the larger bioreactors. Someone didn’t anticipate the heating and coolin…
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Downstream Processing for Cell-Based Therapies
Given the wide variety of CGTs, an array of culture devices (stirred-tank bioreactors, hollow-fiber/packed-bed reactors, gas-permeable membrane reactors, etc.) are used. Therefore, the harvesting prot…
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Perfusion in the 21st Century
Batch processing, in which all raw materials are introduced into the bioreactor at the beginning of the cell-culture process, have largely been replaced with fed-batch systems, in which additional nut…
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Generating a Fully Processed Antibody
Process scale-up to bioreactors
One of the single tagged cell lines was expanded for bioreactor production to confirm that the cell lines could be scaled with similar results. Duplicate 2-L biorea…
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Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…e quantities of cells in a very short period of time and then using that to either inoculate larger bioreactors or run in a continuous manner. That's where PAT comes in handy.
Raman is the prim…
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New Therapies Present Scaling Challenges
Bioreactor size can be increased (scale up), or the number of bioreactors used can be increased (scale out). In addition, mammalian cell culture technology has advanced such that producing multi-kilog…
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Industry Adoption of Single-Use Systems Remains Low
“It is far more common today that biopharma manufacturers are building small economical facilities with several 2000-L single-use bioreactors--20 years ago, the companies were building a facility with…
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Flexible Facilities for Viral Vector Manufacturing
For example, for Duchene muscular dystrophy, the need (at current viral titers and downstream process recoveries) is about 200 L of production bioreactor culture per patient.” The batch size influence…
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Making the Move to Continuous Chromatography
Continuous chromatography systems are designed to be loaded continuously, which is a useful approach when the purification step is connected to an upstream perfusion bioreactor. There are several diff…
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
With the improvements and the rise of SU equipment bioreactors, containers, and physical transfer, a lot of the complexity is removed and even with some reusable equipment, we can still achieve the fa…