Search results for "bioreactor" in Articles / App Notes
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
…offering the advantage of being scalable and readily industrializable using well known stirred tank bioreactors (STRs), as opposed to multi-tray culture systems. To reduce upfront expenses and to ove…
Article
What’s New in Upstream Technologies
The system features a modular, scalable, fixed-bed bioreactor for enhanced upstream processing of viral products, including viral vaccines, viral vectors, and oncolytic viruses. The low-footprint inte…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
The increasing popularity of single-use bioreactor systems and continuous processing techniques have brought both new opportunities and challenges to upstream bioprocessing. Together, these trends hav…
Article
The New World of Biopharmaceutical Manufacturing
Heintz (Solvay): The evolution of single-use containers from several decades ago to today’s gamma irradiation-stable bioreactors has been one of the most significant transformations; it was the impetu…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
Already well-established, mAb production is typically batch-oriented (in this way, making it similar to allogeneic cell therapy production) and characterized by larger single-use bioreactor skids with…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Often in fed-batch processes, the feed volume can be more than 1000 L for a 5000-L bioreactor with 30 to 40% (v/v) feed. To alleviate workload in media preparation and simplify the manufacturing proce…
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Bioprocessing Advances in Vaccine Manufacture
This increase included 78% of those surveyed reporting current use of SUS bioreactors and 92% using SUS filter cartridges at some level in bioprocessing (see Figure 1).
SUS have m…
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Mapping a Route for Cell and Gene Therapy Process Development
The biggest challenge, according to Baghbaderani, is the development of large-scale manufacturing processes using 3D computer-controlled suspension bioreactors with appropriate downstream processes. “…
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Scaling Up Novel Therapies
Bioreactor manufacturers now integrate analytical technologies such as sensors, which allow better prediction and control of changes between scales, into their products. Chromatography and filter manu…
Article
Platform Approach Speeds Process Development
Figure 1: Cell-culture process development concept for Phase I supply including media screening and optimization as well as bioreactor screening optimization modules. For the time scale, one box corre…