Search results for " scalability"
Article
Maximum Output Starts with Optimized Upstream Processing
“The latest iteration of technologies is being developed with scalability, process intensification, and lean principles in mind to ensure quality and reliability for the life of a process,” he asserts…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
Barba, "ABEC launches 6,000 L single-use bioreactor to answer scalability needs," BioPharma-Reporter.com, Sept.12, 2019.
About the authors
Jean-Christophe Drugmand is senior bioprocess archite…
Article
Being Thorough When Transferring Technology
… technology transfer for any modality exist when there are known gaps in scale-down models or if the scalability from the small-scale to large-scale is unknown; for example, in the scale-up of cell-c…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Enhancing Resins Addresses Purification Concerns
Many downstream solutions can be identified in chromatography steps due to the step’s selectivity, versatility, scalability, and cost-effectiveness compared to other steps, says Deorkar. The challenge…
Article
Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…
Article
Platform Approach Speeds Process Development
Depending on the development goals, different development modules can be selected to best fit the anticipated product quality profiles, safety, process robustness, and scalability. A custom set of mod…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
- High productivity, scalability, and single-use compatibility were observed for the superSEC resin.
- Scaling up the SEC resin volumes using the superSEC resin was clearly shown with shorter pur…
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Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches.
By Cynthia A. Challener
For a vaccine to be effective, the components of the disease o…
Article
Best Practices for Selecting a Top-Quality Cell Line
Defining high-quality cell lines
A high-quality cell line will demonstrate high stability, scalability, and high titer, so that it can provide reproducible results—with all product quality attribu…