Search results for " scalability" in Articles / App Notes
Article
A scalable single-use two-step plasmid purification process
The current global demand for biopharmaceuticals is over USD 300 billion, with an estimated growth of ≥ 12% annually. While MAb processes have become much more efficient, production of mRN…
Article
Successful Development of Scalable AAV Processes: Part 2 of 2
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In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist, Bio…
Article
Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
part2
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In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner…
Article
Process Economic Simulation for Scalable Production of Adenovirus
This application note discloses the process economic modelling of a modern start-to-finish adenovirus production process. The novel process was compared with a reference process in both stainless-st…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Overall process scalability and robustness, says Todd Sanderson, senior R&D manager for Pall Biotech, are dependent on the performance of the bioreactor whether it is adherent- or suspension-based. “T…
Article
Maximum Output Starts with Optimized Upstream Processing
“The latest iteration of technologies is being developed with scalability, process intensification, and lean principles in mind to ensure quality and reliability for the life of a process,” he asserts…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
Barba, "ABEC launches 6,000 L single-use bioreactor to answer scalability needs," BioPharma-Reporter.com, Sept.12, 2019.
About the authors
Jean-Christophe Drugmand is senior bioprocess archite…
Article
Being Thorough When Transferring Technology
… technology transfer for any modality exist when there are known gaps in scale-down models or if the scalability from the small-scale to large-scale is unknown; for example, in the scale-up of cell-c…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Enhancing Resins Addresses Purification Concerns
Many downstream solutions can be identified in chromatography steps due to the step’s selectivity, versatility, scalability, and cost-effectiveness compared to other steps, says Deorkar. The challenge…