Search results for " scale up"
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Common Challenges in Cross-Functional Process Development
cross functional
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James Blackwell, President, Windshire Group, LLC, explores common challenges in cross-functional process developme…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
Through its Operation Warp Speed program for COVID-19 vaccine manufacturing, the US government is paying manufacturers and contract service providers to scale up the manufacture of specific vaccine ca…
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Technology Innovations Improve Process Chromatography Performance
…la says
Downstream response to upstream scale-up
What is the downstream response to upstream scale up as the industry sees increasing titers in upstream processing resulting from increased si…
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Next Generation Process Chromatography
Chromatography is an essential part in the production of all biopharmaceuticals. Without it the industry would not be able to produce therapeutics in an economic manner. This is true for monoclonal …
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Manufacturing of Vaccines and Viral Vectors
However, the challenge not only lies in developing a vaccine but also in the ability to scale up the manufacturing process.
In this article, general guidelines for scaling up a viral vector and vi…
Article
Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com
Leveraging automation and a step-by-step approach are keys to success.
By Cynthia A. Challener
Cell lines determine the performanc…
Article
Moving PAT from Concept to Reality
The more information that a company has about its processes, the better decisions it can make, such as about whether to scale up in single-use or stainless-steel equipment,” he explains.
But barri…
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Achieving Process Balance with Perfusion Bioreactors
Advances in single-use technologies, sensors, and cell retention systems facilitate processes designed for the long run.
By Cynthia A. Challener
MG/Stock.Adobe.com
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Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
Fast and efficient process development and scale-up contributes to a shortened time to market. In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capt…
Poster
Adenovirus production in a single-use stirring tank bioreactor system
One alternative is to scale up the production on microcarriers. Another solution is to use suspension-adapted cells, which can facilitate scale-up possibilities. In this work we demonstrate an effici…