Search results for " scale up" in Articles / App Notes
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What is mechanistic modeling in chromatography?
Mechanistic models use computer simulations to decrease the number of experiments needed during process development. The simulatio…
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Top Process Development Trends for 2022 and a Look into 2023
Providing real-world advice from experts was met in the question-and-answer session on oligonucleotide synthesis scale up by Greg Farlow from Cytiva. While this certificate-level interactive course on…
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Introduction to mRNA Manufacturing
Explore the mRNA universe with Cytiva. In this series, our scientists share their journey and insights on mRNA synthesis for research purposes. And they share their advice on how to sca…
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New hydrophobic interaction chromatography (HIC) handbook
Hydrophobic interaction chromatography (HIC) separates biomolecules under mild conditions according to differences in molecular hydrophobicity. HIC is often used as a next step to purify prote…
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Assessing leachables risk over a complete single-use, mAb process
Single-use systems (SUS) in biopharmaceutical manufacturing give advantages such as improved flexibility and plant efficiency, but also raise concern for compounds leaching from the pol…
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Q&A: Oligonucleotide synthesis in process development and scale-up
Farlow
In this video, Greg Farlow, RNA/DNA synthesis product specialist at Cytiva, talks about the typical challenges with oligonucleotide synthesis in process development and key cons…
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Top Process Development Trends for 2021 and a Look into 2022
The COVID-19 pandemic continues to shape bioprocess development trends, and many lessons have been learned from industry’s response to and preparedness for dealing with a public health crisis. Howev…
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The Role of CDMOs in Cell and Gene Therapy Process Development
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An experienced contract development and manufacturing organization (CDMO) can ease scaling and tech transfer.
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Assessing Manufacturing Process Robustness
A structured assessment process can determine compliance to lifecycle process-validation requirements for biopharmaceuticals.
By: Ajay Pazhayattil, Sanjay Sharma, Amol Galande, Marzen…
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Innovative Chromatography Resins Can Improve Purity and Quality
By: Feliza Mirasol
Recent innovations in chromatography resins offer promising advantages in downstream bioprocessing.
With ongoing efforts to increase monoclonal antibody (mAb) productivi…