Search results for " impurity"
Article
Biopharma Advances Demand Specialized Expertise
Jun 15, 2015
By BioPharm International Editors
BioPharm International eBooks
Volume 28, Issue 13
Contract service providers share insights on biopharma market developments and the impl…
Article
Use of Multivariate Data Analysis in Bioprocessing
…eby attributing the source of variation among different raw material lots to uniformity of blending, impurity levels, chemical compatibility, and/or heat sensitivity during the milling process for ba…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time.
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharma…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The aim of this white paper is to demonstrate how Cytiva single-use products can be applied in the field of vaccine manufacturing. The white paper includes a brief discussion around modern vacci…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
The first monoclonal antibodies that will lose patent protection in Europe and the US were made using more stringent impurity level targets than exist now because the technology is more mature and the…
Article
Optimizing KiH bispecific antibody chromatography steps
Bispecific antibodies (bsAbs) are a promising class of therapeutic agents due to their ability to bind to two different types of antigens or two different epitopes on the same antigen. This a…
Article
Introducing the VH3 ligand ELISA kit
Our new VH3 ligand ELISA kit - the latest addition to Cytiva’s impurity portfolio - is the only commercial solution dedicated to testing VH3 ligand leakage. This kit is essential for users of MabSelec…
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
Protein L resins bind to kappa light chain and are often used to purify antibody fragments such as dAbs and Fabs — but they can also be used to remove product-related impurities from bispecif…
Article
Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
The selector chooses based on the structure of your monoclonal antibody, bispecific antibody, or antibody fragment and the impurity profile.
Go to guide
Article
Get Started: Purification of mAb Variants - eLearning
The success of monoclonal antibodies (mAbs) as therapeutics and the multi-domain structure of antibodies has made it possible to create antibody variants, such as bispecific antibodies (bsAbs)…