Search results for " purity" in Articles / App Notes
Article
Improving Process-Scale Chromatography
“Affinity resins are a powerful tool for capture chromatography due to the high degree of purity obtained after a single processing step,” Lynch states.
Ljungqvist adds that for antibody fragments…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Downstream Processing and Purity Analysis
For downstream laboratory-scale purification, performed using standard, non-disposable equipment, approximately 10 L virus harvest from the upstream proce…
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Top challenges in recombinant protein purification process development
The number one challenge they face is that they're unable to get good purity in their first step. If they could use an affinity solution, they could get more than 95% purity already in the first step.…
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Enhancing Resins Addresses Purification Concerns
Each [protocol] needs to achieve high-yielding purification protocols to bring vaccines to the market in short time and in high purity,” Ihre explains. “For some, but not all modalities, platform proc…
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Driving Improved Access to Biosimilars
… it is easy for different manufacturers to produce virtually the same product and to achieve product purity levels of 99% or higher, she says. But she notes that is not always true for biopharmaceuti…
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Combining Purification Techniques in a Multistep Approach
…proach, your protein purification will be successful in terms of either high target protein yield or purity.
In this blog post, learn how to select and combine purification techniques to successf…
Article
Optimizing KiH bispecific antibody chromatography steps
…closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through polishing steps using orthogonal binding principles, hy…
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Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
These target molecules need to be purified to reach required purity and yield.
Selecting an affinity resin for the diverse range of antibodies can be overwhelming. But don’t worry, in this selecti…
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Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
The team assessed scalability from lab- to process-scale units, tracking pressure drop, step recovery, purity, and eluate volumes across multiple cycles.
Article
Genetic Vaccine Platforms Demonstrate Their Potential
“Full focus on SISPQ (safety, identity, strength, purity, and potency) is common to all medicines. However, for genetic vaccines, this means developing a whole new battery of analytical methods, espec…