Search results for " development" in Articles / App Notes
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Paring Down Impurities in Downstream Processing
Myriad choices confront manufacturers before they even consider optimizing downstream processes. Each decision directly influences what final options will be available on arriving at the final…
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How to put mechanistic modeling into practice
Learn about insider recommendations to get started with in silico process development.
Check out our resources on good modeling practice, case studies, and other publications on mechanistic chromat…
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Discussing the Origins of the mRNA Therapeutics Field
Andy Geall, co-founder and chief development officer at Replicate Bioscience, discusses the historical context and buildup of the mRNA therapeutics field.
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Mechanistic modeling quiz: Test your knowledge
The benefit of in silico process development based on a mechanistic model? You can test thousands of purification options in a few hours.
How well do you know mechanistic chromatography modeling? …
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Pulling Out All the Stops in mAb Manufacturing
While the biopharma industry is pushing the barriers with antibody development, it must also contend with contemporary challenges in bulk monoclonal antibody (mAb) manufacturing. The need for…
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Webinar: Optimizing a HIC step with HTPD
This workflow includes the use of high-throughput process development (HTPD) plates to facilitate the choice of resin and initial conditions for column chromatography, and a design of experiments (DoE…
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Establishing a Robust Workflow to Identify GOCHO™ Clones
Our new cell line development platform uses the GOCHO™ host cell line to minimize the risk and timeline to develop high-performing clones suitable for manufacturing.
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Optimization of a HIC step for recombinant protein purification
Follow this step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).
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FAQ: Scale-up and scale-down with mechanistic modeling
A mechanistic model can simplify your process development projects. The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down…
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Optimization of an antibody polishing step
Antibody purification processes are typically developed using a platform approach. Optimal operating conditions for single units are found by altering just a few process parameters with De…