Search results for " development" in Articles / App Notes
Article
Optimization of a two-step purification method for bispecific antibodies
The company is active in the early stages of drug development, from early concepts to clinical phase II studies.
This presentation shows the results from Cytiva collaborating with Alligator to deve…
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Create Digital Twins of your Chromatography Processes
Mechanistic models make it possible to create computer simulations of chromatograms. The simulations, are based on physiochemical phenomena known to occur in chromatography. The benefit of a …
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Good Modeling Practice
How to ensure accurate model calibration for your mechanistic models.
Mechanistic models have become a very promising technique to describe chromatography processes. These models …
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Current Techniques and Challenges Presented in Scaling Between Bioreactors
Knowing the process of the development history and critical parameters is important. For instance, all the ranges for the operating parameters such as the ranges for pH and feed rates. On the other ha…
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New hydrophobic interaction chromatography (HIC) handbook
Hydrophobic interaction chromatography (HIC) separates biomolecules under mild conditions according to differences in molecular hydrophobicity. HIC is often used as a next step to purify prote…
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Take part of the Southeast Asia BioChallenge
Looking to create the next breakthrough innovation? Cytiva is here to support you to bring your molecule to market in the shortest possible time. By applying to our BioChallenge, you stand …
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Rethinking ion exchange chromatography modeling
In the early days of modeling, mechanistic models for ion exchange chromatography were mostly based on stoichiometric equations. A new adsorption isotherm class was introduced in 2021: the co…
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Engage a mechanistic modeling expert – or become one
The application of mechanistic modeling requires expertise for effective use. When planning to implement this ground-breaking technology one essential question must be addressed befor…
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Adsorption isotherm models for chromatography
Read on commonly used models for the thermodynamics of adsorption within a chromatography column.
Indeed, in order to create a complete chromatography model, the adsorption of compon…
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Understanding fluid dynamics within a chromatography column
See how fluid flow effects within a chromatography column are used by mechanistic models.
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