Search results for " manufacturing" in Articles / App Notes
Article
Miniaturization to Become Even More Successful
…he large number of experiments required for the increasing number of targets entering development or manufacturing.
Miniaturization was also one of the most discussed topics at the recent HTPD c…
Article
Gain Efficiency in Process Development
The development of efficient manufacturing processes is a necessity for cost-effective production of biopharmaceuticals. By carefully designing and evaluating your experiments, sufficient informatio…
Article
Optimization of Adenovirus Midstream Purification Steps
Adenovirus (AdV)-based vectors are widely evaluated as vaccine delivery system in preclinical and clinical studies for various infectious diseases. In this application note, studies of midstream pur…
Article
Achieving Efficient Adenovirus Upstream Production
Adenovirus is one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. Adenovirus has also been explored as a viral vector f…
Article
Tools and Solutions for Separation of Charged mAb Variants
Biomolecules, however, exhibit high structural complexity and are often sensitive to alterations in the manufacturing process.
This work aims to demonstrate different strategies to alter the dist…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Chinn compared Robocolumn outputs to manufacturing column outputs. Most challenging are bind-elute applications since there are known offsets, for example, in elution volumes between column formats. T…
Article
Patenting Prospects for Cell-Based Therapies
Cell-based therapies are moving medical treatments forward, but intellectual property uncertainties may delay progress.
By Kevin Noonan
Treatment using cell-based therapies is a rapidl…
Article
N-Glycan Analysis of Biotherapeutic Proteins
Advances in glycoanalysis and glycoengineering will be key to informing research, development, and manufacturing decisions. With glycan research progressing at an accelerated pace over the past two de…
Article
The Extreme Costs of a Bioburden Incident
The cost of bioburden incidents can vastly outweigh the costs of preventing them. Read the bioburden article series.
Article
Sources of Bioburden You Might Have Missed
A problem with traditional mAb manufacturing is that there are so many potential entry points for microbial contamination. There are, however, ways to shut the door on contamination.
The risk …