Search results for " system"
Article
Full Single-Use Downstream Process? Not Any Time Soon.
Here’s why SUTs will not completely replace reuse systems in the near future.
Continue reading in this blog post.
Article
Freedom to Roam During Protein Purification Runs
Have you ever felt tied to your ÄKTA system and itching to get out of the lab? Consider this scenario: You have started a run in the lab and want to get some work done in your office. You may …
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Impurity Testing of Biologic Drug Products
Experts share insights on the various methods used for purity and impurity analysis of therapeutic proteins.
By Adeline Siew, PhD
CA-SSIS/shutterstock.comIm…
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Preclinical Evaluation of Product Related Impurities and Variants
Third, bioassay was performed on the relevant model system (L929 cell line in this case) to determine the biological activity (anti-proliferation in this case). Fourth, empirical modeling of …
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Because these structures are native to living organisms, they are well tolerated by the immune system, which is very important from a therapeutic standpoint. This tolerance can lead to greater potency…
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3rd BioProcessing Asia Preview: Q&A with John Curling
Recognizing the diversity of patient needs across Asia, the lack of attention to many endogenous disease states and the rapidly developing socio-economic pressures on healthcare systems, we developed …
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QbD Improves Cell-Culture Process Control
By applying advanced sensor systems combined with mathematical modeling techniques, one can gain an enhanced understanding of the processes that produce the biologic product.
In addition, this …
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Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system, is demonstrated. Column volume per…
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Single-Use Workflow for Recovery of a Domain Antibody from E. coli Culture Feed in an Automated Manner
This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. Here, a domain antibody (dAb) expressed in E. col…
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Manufacturing Standards Key to Advancing Cellular and Gene Therapies
But the experts sought assurance of security, accuracy, and reliability for Novartis’ complex system for removing blood T-cells from the patient, cryopreserving them for transport to a company proces…