Search results for " system" in Articles / App Notes
Article
High Throughput Protein Purification at a Glance
Within the Human Protein Atlas project, scientists are using ÄKTA systems to purify up to 180 protein samples per week. Frida Henningson Johnson, Annelie Cajander, and Anne-Sophie Svensson sha…
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Transformative Medicines Challenge FDA and Manufacturers
While systems that edit DNA are hard to reverse, changes from RNA-editing procedures disappear over time, which can be a plus, or a liability, depending on the situation. Although the long-term effect…
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ADC Development Robust Despite Lackluster Performance
An ADC enables the specific delivery of chemotherapeutics to tumors while avoiding systemic exposure to the cytotoxic compound (1).
Because the stable linkers conjugate cytotoxic molecules to t…
Article
Fusion Proteins Pose Manufacturability Challenges
Roche/Genentech is focused on cytokine fusion proteins, or immunocytokines, which provide targeted delivery of the cytokines into tumor cells to stimulate the local immune system and avoid responses i…
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Witnessing Major Growth in Next-Generation Antibodies
Application bispecific antibodies are also being applied to diseases of the central nervous system with the development of brain-penetrant antibodies.
“Hence, next-generation biotherapeutic techno…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
The problem of copying biologics
Biologic drugs have revolutionized the pharmaceutical industry by attacking disease using the mechanisms of the cell and immune system. These therapies are fragile…
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Improving Process-Scale Chromatography
Equipment suppliers have also introduced or are developing continuous chromatography systems for use at the lab, pilot, and manufacturing scales. Both Cytiva and Pall have systems based on countercurr…
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Walk Away and Do More Screening Preps
Learn how an ÄKTA pure protein purification system can be modified to increase throughput of mAb purifications and decrease hands-on time.
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
Robust systems were required to prevent exposure.
Present situation
Several fundamental elements are mandatory for any systematic effort to successfully prevent exposure to animal-…
Article
Generating a Fully Processed Antibody
This is mainly due to problems getting different levels of protein expression for each of the multiple proteins needed for function and the ability of the system to obtain stable expression of each of…