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Article Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
With an increased binding capacity and new high-flow agarose bead design, the productivity of current chromatography columns and systems can be improved without costly capital expenditures, making mor…

Article Current Innovations and Practices To Address Microbial Contamination in Downstream Bioprocessing
Improved ways of working in the manufacturing facility have been facilitated by supplier developments in automation, closed systems, and single-use solutions. Learn more on how to address bioburde…

Article Bioburden Control in the Biopharmaceutical Industry
Supply air ducts with associated high efficiency particulate air (HEPA) filters and heating, ventilation, and air conditioning (HVAC) systems should be regularly monitored and effectively maintained t…

Article Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
To further reduce the time and space required, ready-made stock solutions delivered in disposable bags were connected directly to the Inline Conditioning system and feedback regulation of the final bu…

Article Contract Manufacturing Through the Years
Developments in manufacturing technologies such as vastly improved yields for biologics, single-use systems, and continuous processing simultaneously require CDMOs to invest in new technologies while …

Article Asked and Answered: Your Questions on Ion-Exchange Chromatography
The questions are organized in by chief concern, and include buffers, experimental design, LC system and configuration, resin and column selection, specific applications, as well as troubleshooting an…

Article Hybrid Bioprocessing: A Q&A with Andrew Sinclair
Is there a difference between upstream and downstream? The main benefits attributed to SU are achieved in hybrid systems by selectively tackling those areas that give rise to SIP, CIP, and multi-f…

Article High Throughput Protein Purification at a Glance
Within the Human Protein Atlas project, scientists are using ÄKTA systems to purify up to 180 protein samples per week. The project uses antibodies to study the localization of proteins in huma…

Article Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
This includes single-use technology, which has been shown to reduce capital and operating costs by 40%-50%,1 and modular and flexible manufacturing systems, which are seen by many as a way for biophar…

Article Single-Use Extractables and Leachables: Cytiva's Alignment with the BPOG Protocol
Trade organizations, such as the Bio-Process Systems Alliance (BPSA) and suppliers have derived their own approaches to testing. For end users who are adopting single-use (SU) equipment as a manufactu…

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