Search results for " bioreactors"
Article
Securing the Single-Use Supply Chain
Dual sourcing is one of many possible solutions to securing the supply chain.
Single-use systems (SUS) have become established in biopharmaceutical drug development. As confidence in the technol…
Article
High-Throughput Process Development in an Historical Environment
Several new equipment and innovations were introduced to the market, such as micro bioreactors in the 10-15 ml scale, controlled by an automated workstation. As an example of their utilization, Chris …
Article
Challenges and Trends in Biopharma Facility Design
In the case of producing a blockbuster drug, a large-scale stainless steel facility might actually be the most economical choice, especially if you have low titers and are starting from high-volume bi…
Article
Pharma Investments Reflect Key Industry Trends
The company is also investing $70 million to complete the second phase of an expansion of its East Greenbush, NY facility, which will include the addition of two 10,000-liter bioreactors.
Roche: F…
Article
Q&As with Industry Leaders
…pplication, R&D, Cytiva
Current Techniques and Challenges Presented in Scaling Between Bioreactors
Jeanne Linke Northrop, BioPharm International
Andreas Castan, Strategic Tech…
Article
Q&A with Industry Leader Konstantin Konstantinov, Genzyme Vice-President
This week we speak with Konstantin Konstantinov, Genzyme Vice-President Late Stage Process Development, about developments in continuous processing.
Q: You’re part of an upcoming sym…
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
Areas considered for experimental scale include, but are not limited to:
• Aspect ratios of bioreactors and mixing tanks
• Impeller number, size, and location
• Aeration method and effecti…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
A prototype Protein A resin is evaluated for purification performance, reusability, and cost performance.
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic …
Article
The Development and Application of a Monoclonal Antibody Purification Platform
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.
The following ar…
Article
Quality by design for biotechnology products—part 1
A PhRMA Working Group's advice on applying QbD to biotech.
By Taruna Arora, Roger Greene, Jennifer Mercer, Paul Tsang, Meg Casais, Stuart Feldman, Jutta Look, Tony Lubiniecki, Joseph Mezzatesta,…