Search results for " bioreactors" in Articles / App Notes
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
Article
Remote Monitoring and Big Data Advance Upstream Automation
“Longer term there will be sufficient established PAT solutions, particularly in upstream bioprocessing, to have fully ‘lights-out’ manufacturing, with samples pulled automatically from bioreactors an…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
As the industry has matured, effective manufacturing platforms and analytical tools and technologies appropriate for fed-batch manufacturing in stainless-steel or single-use bioreactors have also adva…
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Moving PAT from Concept to Reality
In bioreactors, in-line sensors measure pH, temperature, dissolved oxygen (DO), and carbon dioxide; in-line optical sensors (Raman, NIR) are coupled with multivariate modeling to measure metabolites. …
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Process Development: What May Lie Ahead in 2018?
Single-use bioreactors, for instance, are increasingly available from a host of vendors, and suppliers of such technology have made “significant advances in film technologies, bioreactor designs, stir…
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Platform Technologies Improve Protein Expression
He points to the use of high-cell-density, fixed-bed bioreactors for adherent cell culture as an exciting new development. “With these bioreactors, it is possible to increase cell densities from 10-20…
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Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
Cell-culture technology
Cell-culture technology enables the use of raw materials that are readily available and not threatened by pandemic events, as well as closed-system bioreactors that reduc…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
Cell culture was performed using numerous methods, including roller bottles and stirred tank bioreactors operated in perfusion, batch re-feed, or fed-batch mode (1).
Starting in 1986 with the lic…
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Interactive eBook - Understand and unlock the potential of digital scaling
Ready for smarter scaling? Explore the possibilities with a digital process to reduce time and costs associated with your operations. Get started by downloading our free eBook.
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Article
Future-proof your AAV process with a complete producer cell line – just induce and grow
…patient populations
• Take a deep dive into data on robust scaling to large-scale stirred tank bioreactors
• Learn how Cytiva can help you optimize your upstream processing — with cells, medi…