Search results for "expression"
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
Today, a typical process accumulates titers of 1-5 g/L, but expression levels as high as 10-13 g/L have been reported (5). The increase in upstream productivity creates a subsequent demand on downstre…
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Article
Evaluating the Use of Continuous Chromatography
Continuous processes continue to advance in bioprocessing. In downstream processing, continuous chromatography is gaining traction in the purification of protein therapeutics. As the biopharma…
Article
A Closer Look at Affinity Ligands
Large-scale manufacturing of a therapeutic monoclonal antibody (mAb) starts with the expression of the antibody in mammalian cells, typically CHO [Chinese hamster ovary] cells, followed by a series of…
Article
Paring Down Impurities in Downstream Processing
Biopharmaceutical expression systems range from yeast and insects to mammals and plants. Bioreactors to house these systems might be stirred-tank, air-lift, fixed-bed, hollow-fiber perfusion, or suspe…
Webcast
Peptalk 2024 – San Diego
Conference tracks cover a range of topics including antibody engineering, bispecific antibody development, characterization of biologics, viral vector engineering, and protein expression platforms. Le…
Article
rAAV Production Using HEK293 Cell Line and Transfection Medium
Improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactor using HyClone™ peak expression medium.
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Webcast
Recovery of Biological Products XIX
proteins, peptides, cell and gene therapies including viral vectors and nucleic acid-based products ), a range of expression systems, universal and personalized therapies, and different facility desig…
Article
Increasing mRNA capabilities and capacity for growing market needs
The rapid development of innovative vaccines allowed for the pharmaceutical industry to deliver its first tools in the fight against the COVID-19 pandemic.
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Article
Maximum Output Starts with Optimized Upstream Processing
“Efforts have targeted the development of new expression technologies, parallel tracking of activities that are not on the critical path, and implementing high-throughput, small-scale technologies,” c…