Search results for " impurities"
Article
How to develop a scalable rAAV process
Adeno-associated virus (AAV) is the most common vector for gene therapy, yet there’s much room to improve production, purification, and analytics. Here we present the latest updates to our wor…
Article
From cells to purified capsids: How to develop a scalable rAAV process
Adeno-associated virus (AAV) is the most common vector for gene therapy, yet there’s much room to improve production, purification, and analytics. In this webinar we present the latest upd…
Webcast
Controlling Cell-Culture Process Variability
Impurities in raw materials are a risk to your cell productivity and protein quality. That is why we created a transparent, multi-source supplier network for cell-culture materials.
Article
Virus and exosome purification: harness core bead technology
Using core bead technology to fine tune impurity removal and maximize recovery of
large entities.
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Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
If you have an upstream process that is generating material that has too many impurities or too much variation in the glycosylation pattern, then folks are going to say, “I can't clean this up with ch…
Article
Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
And the good news is that you are able to do this, not only for your molecule of interest, but also for all the impurities.
Nick, how do you do this in reality?
Whitelock: Absolutely. So…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Digitalization of bioprocessing operations, equipment, and facilities can improve workflow and output, but maintaining data integrity is a concern.
By Feliza Mirasol
The advancement of digit…
Article
Manage HCPs and Enhance Your Route to Market
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Host cell protein (HCP) management is critical to biologics development—and getting it wrong could delay your development cycle. Learn how the right HCP strategy can enhance…
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
Creativity and collaboration are required to overcome complex method development challenges.
By Kelvin H. Lee and Mark Lies
…
Article
Virus-like Particles as Therapeutic Moieties of the Future
In addition, various non-desired impurities such as media components, debris, host DNA or RNA, and exosomes may be retained in the final product (14). Modification of VLPs may also affect their downst…