Search results for "Upstream"
Article
Tools and Processes for Mature and Emerging Therapies
In April 2019, at the INTERPHEX trade show in New York City, vendors of bioprocessing equipment and materials announced improvements to existing platforms, added options for upstream and downstream sy…
Article
Case Study: Oncolytic Adenovirus Production
This case study describes a robust upstream process and downstream process for oncolytic adenovirus production. Purity of final samples meets regulatory requirements.
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Poster
Perfusion Media Development for Scalable Processes
Cell culture perfusion processes are considered optimal for a truly integrated continuous biomanufacturing pipeline. The nutrient-rich but balanced media should be designed to support very low cell-sp…
Article
2019 HTPD Conference Is Announced. What Happened Last Time?
HTPD 2019 will cover process development spanning upstream through downstream processing for both mAbs, Ab-like molecules as well as novel biomolecules. Sessions will also include integrated P…
Article
Case Study: Process for Production of Oncolytic Adenovirus
The case study describes a process from upstream cell culture to downstream purification, using scalable modern tools and technologies.
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Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
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Perfusion processes have many advantages such as being favorable for product quality and supporting efficient facility utilization by offering the possibility…
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.
An IgG1-producing CHO cell …
Poster
A Scalable Adenovirus Production Process
To meet these needs, a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies was developed.
The novel process is easily sc…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
Optimizing Late-Stage and Commercial Cell-Culture Processes
Late-stage and commercial biomanufacturing pose a challenge to cell-culture processing.
By Feliza Mirasol
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Poster
Development of DoE based fed-batch strategies for high-producing CHO cell cultures
Fed-batch culture is commonly employed to maximize cell and product concentrations in upstream mammalian cell culture processes. Typical standard platform processes rely on fixed-volume bolus feedin…