Search results for " virus"
Poster
A Scalable Adenovirus Production Process
The process has process economical advantages compared with an existing reference process and includes new technologies and convenient and sensitive virus titer assays.
Article
The Challenge of Disruptive Technologies in Bioprocessing
Thermo Fisher Scientific has commercialized three POROS CaptureSelect AAV affinity resins to establish industrialized platforms for the purification of adeno-associated virus (AAV). The move is meant …
Article
Developing an Efficient Adenovirus Downstream Purification Process
Adenovirus is also explored as a potential viral vector for gene therapy and as an oncolytic virus. This application note describes the development of downstream chromatography steps for purification …
Article
Achieving Efficient Adenovirus Upstream Production
Adenovirus has also been explored as a viral vector for gene therapy and as an oncolytic virus. This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor …
Article
Modern Manufacturing Key to More Effective Vaccines
In commenting on the effectiveness of this year’s flu vaccine, Gottlieb noted that products made with cell-based methods appear more effective in protecting against the H3N2 virus than egg-based produ…
Article
Industry Adoption of Single-Use Systems Remains Low
Now we have a complete portfolio of single-use upstream and downstream systems for bioprocessing, including rocking and stirred tank bioreactors, sensors, smart mixers, filtration pump skids, virus in…
Article
FDA Framework Spurs Advanced Therapies
Kolata, “Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage [4],” New York Times, Nov. 27, 2017.
Article
Process Development: What May Lie Ahead in 2018?
In addition, the agency approved Luxturna (voretigene neparvovec-rzyl), the first FDA-approved gene therapy for a genetic disease and the first adeno-associated virus vector gene therapy approved in t…
Article
Platform Technologies Improve Protein Expression
Platform technologies facilitate development and accelerate commercialization of protein therapeutics.
By Cynthia A. Challener
Speed to market is essential in the biopharmaceutica…
Article
Improvements in Protein A Chromatography
… provides high yield while providing up to 3 logs of host cell protein removal and 4 logs of DNA and virus removal. Resins are robust enough to be cleaned with caustic and re-used hundreds of times. …