Search results for "development"
Article
Alkaline stability of Fc and VH3 binding in protein A resins
In the development of antibody purification protocols, you need to know your Ab molecule and its possible affinity binding sites for the chromatography resins. In this study, we have looked at…
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Simplify-bioreactor scale up and scale down: applications and tools
Scaling the physical environment in a bioreactor is a frequent task in each product development project. A well-designed scaling strategy, workflows, and easy-to-use tools will facil…
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Webcast: Repeatable, automated SPR titer assay for adeno- and adeno-associated viruses in crude samples
Fredrik Sundberg at Cytiva shares our recent SPR assay developments for measuring adenovirus and adeno-associated virus titers.
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Late stage failures of monoclonal antibodies
Despite the significant developments that have happened in clinical trial design and the considerable experience that the biopharma industry has gained in the past three decades, therapeutic…
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Increasing mRNA capabilities and capacity for growing market needs
The rapid development of innovative vaccines allowed for the pharmaceutical industry to deliver its first tools in the fight against the COVID-19 pandemic.
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Optimizing capture and polishing steps in an rAAV purification process
In this article, we show how we developed an efficient purification process for recombinant AAV (rAAV). The chromatography purification described includes affinity capture to maxi…
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mRNA vaccines: current trends and perspectives
The promise and challenges of mRNA vaccine development.
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Webcast
Conference: Chromatography modeling days
If you’re a process developer, modeler, or innovator in the biopharma downstream community, you are invited to share and discuss success stories, best practices, and current challenges and pain poin…
Article
Cytiva to provide Arranta Bio 'idea to injection' solutions for integrated manufacturing of mRNA products
Cytiva will provide its FlexFactory single-use manufacturing platform to Arranta Bio ("Arranta"), a leading contract development and manufacturing organization (CDMO) for use in manufacturing mRNAv…
Article
In silico Approaches towards Automated Biomanufacturing
The goal of manufacturing is to control and maintain a commercial process capable of consistently producing a drug of the highest quality and safety. As part of manufacturing science and t…