Search results for "development"
Article
How to Address Bioburden Challenges: Insights and Tips
Bioburden control is an area of serious concern for anyone making mAbs or other biologicals. Manufacturers’ efforts to avoid microbial contamination are today being complemented by developments from…
Article
Tips for Protein Purification Method Editing
Protein purification questions and answers from ÄKTA club web chat.
Find out how to quickly generate tailored automation methods in your UNICORN™ software in this blog.
Article
Accelerated flavivirus vaccine production with modern tools and solutions
Flavivirus vaccine development and production constitute many challenges and can be both space-and resource-consuming. This white paper gives an overview of modern tools and solutions, adding flexib…
Poster
Collaborating to address the bioburden challenge
For example, development of Protein A resins to withstand high NaOH concentrations and investigations of an oxidizing agent for sanitization are conducted.
Poster
Validation of the Production of Influenza Virus
This application note describes the validation of the single-use ReadyToProcess WAVE 25 rocking bioreactor system in production of influenza virus from Vero cells in microcarrier-based cultures. A 2…
Article
Evaluating E&L Studies for Single-Use Systems
Extraction studies demonstrate approaches for evaluating single-use bio-pharmaceutical manufacturing materials.
By Irene Cecchini, Daniele Mastroianni, Silvia Rocchi, Gabriella Angiuoni
Biop…
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
Compared with facilities using stainless steel columns, the use of disposable ReadyToProcess Adsorber membranes minimizes the number of non-value-adding steps in process development, such as cleaning …
Poster
Effects of feeding strategy on CHO cell performance in fed-batch cultures
This work demonstrates the development of a fed-batch process for a Chinese hamster ovary (CHO) cell line producing a monoclonal antibody (mAb). The results emphasize the importance of an appropriate …
Article
Increase Efficiency in Experimentation with Design of Experiments
Setting up an efficient study can help you save time and allow you to get the most out of screening and optimization experiments during method development. Also, good planning and relevant experimen…
Article
Walk Away and Do More Screening Preps
Developing a process or looking for a clone of interest often requires screening large numbers of samples. Many analyses require purified protein, and substantial hands-on time might be allocated to…