Search results for " bioreactor" in Articles / App Notes
Article
Implications of Cell Culture Conditions on Protein Glycosylation
The choice of host cell and the bioreactor conditions used in bioproduction of proteins significantly affects protein product quality. This is due both to the structural complexity of proteins themsel…
Article
Continuous Manufacturing: A Changing Processing Paradigm
“Currently, only a minority of bioreactors are specified with perfusion capability; however, there is a clear awareness that new facilities must be flexible and adaptable to perfusion technology,” ass…
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QbD and PAT in Upstream and Downstream Processing
This approach can lead in the determination of CQAs for the cell production bioreactor unit operation. Upstream outputs classified as CQAs have proven to be controversial, because the bioreactor is so…
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Maximum Output Starts with Optimized Upstream Processing
She points to the mAb sector where stainless-steel bioreactors with tens of thousands of liters of capacity were commonly used for cell culture, but today have been replaced with single-use (SU) biore…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Of the nearly 20 technologies identified, the top technologies this year included single-use bioreactors (noted by 45.9% of respondents), followed by cell culture media including optimization, and the…
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Unifying Continuous Biomanufacturing Operations
“For continuous virus production, multi-stage bioreactors are needed, with configurations that can be either cascades of continuous stirred-tank bioreactors (CSTRs) or CSTRs followed by tubular reacto…
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Being Thorough When Transferring Technology
For example, when single-use bioreactors were a nascent technology to the industry, there were reports that some bags melted on the larger bioreactors. Someone didn’t anticipate the heating and coolin…
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Downstream Processing for Cell-Based Therapies
Given the wide variety of CGTs, an array of culture devices (stirred-tank bioreactors, hollow-fiber/packed-bed reactors, gas-permeable membrane reactors, etc.) are used. Therefore, the harvesting prot…
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Perfusion in the 21st Century
Batch processing, in which all raw materials are introduced into the bioreactor at the beginning of the cell-culture process, have largely been replaced with fed-batch systems, in which additional nut…
Article
Generating a Fully Processed Antibody
Process scale-up to bioreactors
One of the single tagged cell lines was expanded for bioreactor production to confirm that the cell lines could be scaled with similar results. Duplicate 2-L biorea…