Search results for "buffer" in Articles / App Notes
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
For support infrastructure as it relates to hold vessels for buffers etc, it is nearly always good to incorporate as much as possible taking account of the practicalities
Continuous bioprocessin…
Article
Unifying Continuous Biomanufacturing Operations
… footprint, higher cell concentration/higher productivity per volume, lower residence time, reduced buffer consumption, reduction of human error, the elimination of hold steps (which means safer proc…
Article
Improvements in Protein A Chromatography
The Protein A step is platformable so that the same buffers and conditions can be used for many different clinical antibody candidates. This allows for fast step development. Alternative technologies …
Article
Speed and Flexibility Are Dual Goals for Biopharma Operations
What new technologies and products are impacting bioprocessing operations?
Recent product introductions for bioprocessing operations—such as advances in bioreactor technology, media, buffers, and …
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
Compared with conventional chromatography, using stainless steel columns, the use of ReadyToProcess Adsorber membranes can help reduce capital investment, consumption of buffers and other process liqu…
Article
Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…Facility Opens: KUBio in Hangzhou
Lessons Learned Accelerate Vaccine Development
Overcoming Buffer Challenges With In-Line Conditioning
A Platform Approach to Purification of Antibody Fra…
Article
How to Optimize Protein Desalting
Most protein purification workflows require desalting, buffer exchange, or both at one or more steps. But how do you determine which method to use? And how do you choose the right product for your n…
Article
Going Small to Achieve Success on the Commercial Scale
Additional parameters that are considered include buffer preparation and feed stream. “The ideal model behaves identically to the scaled-up process such that the results obtained in the lab exactly pr…
Article
Selecting a Comprehensive Bioburden Reduction Plan
Filtration may be used for cell-culture media or buffers. Chromatographic steps, low pH, and chemical inactivation provide virus reduction during processing. Virus and sterile filtration prior to fina…
Article
Using Single-Use Technologies in Downstream Processing
Some examples are filtration systems, buffer preparation systems, and sampling/dispensing systems. Key advantages of using single-use systems are speed of implementation, which is crucial for high-imp…