Search results for " growth"
Article
Mapping a Route for Cell and Gene Therapy Process Development
While cell and gene therapies differ in many ways, some of the best practices for process development and validation are similar.
By Cynthia A. Challener
…
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
Small-scale microcarrier cultures were optimized using spinner flasks by closely monitoring cell growth, viability, and morphology. The results were used for scaling up the process to a ReadyToProcess…
Article
Securing Today’s Biomanufacturing Supply Chain Using Transformative Supply
…that includes, for example, DNA and RNA molecules and cell and gene therapies, is anticipated as the growth continues. Responding to the rapidly changing requirements of these novel therapies means t…
Article
New Therapies Present Scaling Challenges
In the roller bottle process, cells grow and attach to the surface of cylindrical bottles and are bathed in growth media as the bottle is rolled on a rack inside a temperature-controlled chamber. To i…
Article
Best Practices for Selecting a Top-Quality Cell Line
Factors such as cell growth and metabolism, as well as product quality attributes like glycosylation distribution, are closely related to the culture medium, and thus many cell-culture media component…
Article
Design Considerations for a Commercial Cell and Gene Therapy Facility
“Getting these conditions just right requires balancing the cell line, expression system, media and growth factors, and bioreactor conditions—such as stir rate and gas transfer. For biologics and vira…
Article
Jefferson Institute for Bioprocessing Opens Near Philadelphia, PA
“Biomanufacturing is going through an unprecedented period of innovation in new products and growth in legacy therapeutics that promise many new jobs over the next decade and beyond,” JIB executive di…
Article
Faster Flavivirus Vaccine Production
The approach helps determine which components in the media will have the most beneficial effect on cell growth. Surface Plasmon Resonance (SPR) analysis during process development provides data about …
Article
Automating the Biomanufacturing Process
As a result, data integration is needed to handle the huge increase in product data from this growth to ensure that these raw data become information that can be used to control and improve the proces…
Article
An Analytical Approach to Biosimilar Drug Development
…ey are increasingly required to shift focus to large-molecule characterization and analysis with the growth of biotherapeutics in the pharmaceutical industry pipleline (2).
As a result,…