Search results for " protein" in Articles / App Notes
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…it's really at because every sample that has to go to an analyst, whether it's a small molecule or a protein or a biologic, takes time to run on a system. It takes a dedicated person to run that samp…
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Tips for Purifying and Analyzing Cryo-EM Samples
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Cryogenic electron microscopy (cryo-EM) provides possibilities to determine structures for more challenging proteins, such as membrane proteins and larger protein compl…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Studies and rankings showed that aggregation and Protein A fragmentation were crucial CQAs, Adkins said. Upstream, the most important CQAs include glucose concentration and cell mobility; downstream, …
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Preclinical Evaluation of Product Related Impurities and Variants
For example, the cystine/DTT ratio is governed by the number of cysteine residues in the protein and thus the number of disulfide bonds necessary for the protein to assume its functional native confor…
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ADC Development Robust Despite Lackluster Performance
Oncomatryx’s approach is to develop precision drugs that target proteins located in the tumor microenvironment, which it believes is a novel route to cancer treatment because it is directed at stromal…
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From Darwin to Recombinant Fc Multimers
IgG market will continue to dominate with 46% of market, followed by albumin, 18%, John Perkins stressed the importance of other plasma proteins to have a good process economy.
Some of the …
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Being Thorough When Transferring Technology
According to Mike Ultee, principal of Ulteemit BioConsulting, companies often fail to provide complete information about their biopharmaceutical or protein. He suggests that companies should allow eno…
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Affinity Chromatography Handbook in 3 Volumes
The technique offers high selectivity, hence high resolution, and usually high capacity for the protein(s) of interest. Purification can be in the order of several thousand-fold and recoveries of acti…
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Optimizing Resin Performance with Disposable Chromatography Solutions
The chromatography medium is the means by which protein purification is performed, and it must perform as expected, otherwise the purity of the drug can be impaired. Customers have expressed that they…
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Register to the Chromatography + Filtration Virtual Summit 2024
Learn from presentations, live Q&A, and panel discussions with your peers on recent advances in antibody, antibody variants, recombinant proteins, and gene therapy downstream applications.
Agen…