Search results for " Mab"
Article
Report from the 6th International HTPD Conference
The QSAR model by Merck has been developed and trained with 10,000 data points from historical data on 40 proteins (mainly mAbs but a few Ab variants) and 51 resins. Calculated descriptors for protein…
Article
Fundamentals of hydrophobic interaction chromatography
…:
* recombinant proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Browse this HIC resour…
Article
Maximum Output Starts with Optimized Upstream Processing
She points to the mAb sector where stainless-steel bioreactors with tens of thousands of liters of capacity were commonly used for cell culture, but today have been replaced with single-use (SU) biore…
Article
A Continuous Confidence Boost
In this case study, Shanghai Henlius Biotech describes its approach to continuous mAb bioprocessing. Insights, experiences, and challenges addressed from their implementation are shared.
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Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Because nearly all mAb biosimilars are produced in mammalian cells, they exhibit different post translational modifications (PTMs), which results in heterogeneity. This could be attributed to differen…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Demand for mAbs, for example, is expected to increase by one or two orders of magnitude, and it may not be economical to cover this demand increase using current bioprocessing technology, according to…
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system, is demonstrated. Column volume per…
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
• The increased upstream titers in mAb production seen in recent years may make the Protein A capture step a bottleneck.
• Protein A columns columns are also more prone to bioburden contamination…
Article
How to Address Bioburden Challenges: Insights and Tips
Another important area where suppliers can contribute is sanitization and storage procedures for protein A chromatography resins, which are widely used to purify mAbs.
Learn more about insights an…
Poster
Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
In this application note, the effects of treating MabSelect SuRe protein A affinity resin with 20 mM PAA every fourth process cycle for more than 100 cycles were investigated. The results show that t…