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Article Fusion Proteins Pose Manufacturability Challenges
The unique structures of fusion proteins lead to expression, heterogeneity, and stability issues. By Cynthia A. Challener Fusion proteins are engineered proteins that contain domains from di…

Article Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …

Article Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
The year ahead is expected to be marked by increased biosimilar development, lower drug prices, and better quality drugs. The global biopharmaceuticals market was valued at $162 billion in 2014 a…

Article Vaccine Development Faces Urgency and Challenges
Global outbreaks energize vaccine R&D and drive production modernization. By Jill Wechsler The Ebola outbreak in 2015 and the current stampede to develop a new vaccine to combat the Zika vir…

Article A Q&A With Jeff Carter on Trends in Single-Use Technologies
Process Development Forum speaks with Jeff Carter, Strategic Projects Leader at Cytiva, and first Vice Chair on the executive board of the Bio-Process Systems Alliance (BPSA). What general trend…

Article Fluid Handling in Biopharma Facilities
Particularly, less investments in clean in place and sterilize in place (CIP/SIP) and automation infrastructure are main drivers. For nonsterile fluids, this major point is not important. In addition,…

Article A Bright Future for the Plasma Fractionation Industry
There is still a very bright future for the plasma fractionation industry. That was one of the conclusions reached when the 9th Plasma Product Biotechnology (PPB) meeting ended on the beautiful isla…

Article Drug Discovery and Development in India
Apr 01, 2015 By Jane Wan BioPharm International Volume 28, Issue 4 Indian pharmaceutical companies’ entry into the drug discovery and development field dates back to the early 1990s …

Article The Bullish Outlook for Biosimilars
Regulatory pathways are being defined, and major players and investments are lining up. Most importantly, a number of patents are set to expire on leading biologics, and financially strapped payers ac…

Article Application of Quality by Design to Viral Safety
A quality-by-design approach defines a range of potential viral contaminants of source materials and can be used to effectively achieve viral clearance. Oct 1, 2014 BioPharm International …

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