Search results for " cell-culture" in Articles / App Notes
Article
Modeling Bioreactor Performance
Challener
Bioreactor design, including the geometry of the tank and impeller and the locations of inlets, has a direct impact on the performance of cell-culture and fermentation processes. Modelin…
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Raw Material Variability
Raw materials have a wide definition: cell-culture media; excipients; chemical additives; detergents; manufacturing process agents, for example, anti-foam agents or even product contact materials like…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
As a consequence, downstream processing must accept and handle higher titers of mAbs in harvested cell-culture fluid (HCCF), and vendors of mAb purification technologies must develop chromatography re…
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Cell-free Expression Systems Pose Cell Culture Alternative
Traditional cell-culture based biomanufacturing is a mature technology; however, it is tied to a living cell, which necessitates a great deal of complexity. That complexity ranges from the creation of…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
…y in only eight months, compared to the two to three years (or more) usually required to build a new cell-culture facility. This speed was also made possible by Lonza’s pre-investment Ibex Dedicate i…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
There are some sensors currently used to monitor different parameters of cell-culture processes in near real-time, such as pH, turbidity, dissolved oxygen, carbon dioxide production, key metabolite pr…
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Improving Upstream Predictability
Verlenden expects to see greater use of perfusion-developed cell lines, expansion and perfusion cell-culture media, cell retention systems, single-use bioreactors developed for perfusion applications,…
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New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
Article
Best Practices for Selecting a Top-Quality Cell Line
Factors such as cell growth and metabolism, as well as product quality attributes like glycosylation distribution, are closely related to the culture medium, and thus many cell-culture media component…
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
In contrast, upstream concerns, “optimizing cell-culture systems,” was number one in 2003.
Exciting technologies have come and gone over the past 15 years. For example, back in 2003, transgenic…