Search results for "Cytiva" in Articles / App Notes
Article
Key Process Considerations for Therapeutic Oligonucleotides
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Learn more about scalable solutions for developing and manufacturing oligonucleotide therapeutics.
Article
Achieving the Required Buffer Quality with Inline Conditioning
Buffer production often becomes a limiting factor when the goal is to design more flexible facilities. To overcome this, Janssen Biologics BV decided to investigate inline conditioning (IC) technology…
Article
Sanitization of AxiChrom™ Columns Packed with Chromatography Resin
This study evaluates sanitization methods based on 1 M sodium hydroxide (NaOH) as sanitization agent using methodology previously developed for peracetic acid (PAA).
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Article
How Do I Fix Asymmetrical Chromatography Peaks?
All good chromatography books say that the peaks in the chromatogram should be symmetrical, but what about real life in the lab? There are many different causes to “fronting” or “tailing” peaks, but…
Article
How to Optimize and Scale Up AAV Production
In this article from a roundtable discussion, four experts from academia and industry met to discuss challenges in refining and scaling up AAV production pipelines to meet the increasing demand for …
Article
Troubleshooting Protein Purity Issues – Top Tips
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What’s the point of protein purification? Obtaining pure proteins, of course! If you are having difficulties obtaining the purity you need, these troubleshooting tip…
Article
The Role of CDMOs in Cell and Gene Therapy Process Development
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An experienced contract development and manufacturing organization (CDMO) can ease scaling and tech transfer.
Article
Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quic…
Article
Developing a New Biologic Drug: Regulatory Challenges and Considerations
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Key milestones and planning ahead for compliance when bringing a new biologic drug to market