Search results for "Cytiva" in Articles / App Notes
Article
Simple Fed-Batch Process Development for a Knockout Cell Line
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This workflow improved titers by 500% compared with Chinese hamster ovary cell culture in basal medium.
Article
mRNA Processing Workflow for Vaccines and Therapeutics
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Learn more on key considerations when setting up a messenger RNA (mRNA) process with this infographic.
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Bind, Cut, Elute — Easy Affinity Tag and Protease Removal
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This blog post discusses automated methods for removing an affinity tag and the protease. The tag is cleaved while the protein is still bound to the affinity re…
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Traceability in Western Blot Imaging: Considerations for GxP
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Densitometry analysis of gels is a key part of quality control in the pharmaceutical drug release process. In regulated environments, electronic record-keeping can improve both tra…
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Guide to Polishing Chromatography in Process Development
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This article shares the factors you should consider when developing your polishing steps—from the basics to the typical challenges faced, and how to overcome them.
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Meeting the Process Development Challenges of a Diverse Biologic Pipeline
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In the current biopharmaceutical landscape, developers are constantly encountering new and diverse biological molecules with complex structures. While these novel biolog…
Article
Sanitization Opportunities for Protein A Resins
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Bacterial endospores present a challenge in bioproduction due to their resistance to common sanitization procedures using high concentrations of NaOH. Several protein-b…
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Perfusion N-1 – A Way to Improve the Fed-Batch Production Process
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In this article, we show how the conventional N-1 seed train step was replaced by a high-density perfusion and how the production bioreactor can be seeded at a 10-fol…
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A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
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mRNA Therapeutics and Vaccines – Key Process Considerations
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Learn more on key considerations and strategies for process development and scaling up in our new web hub for mRNA therapeutics and vaccines.