Search results for " scalable"
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Maximum Output Starts with Optimized Upstream Processing
Furthermore, Chilima observes that by using scalable technologies that have representative scale-down models early in the process development, companies are able to evaluate the capacity needed early …
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
At the same time, the production platform selected to manufacture clinical material must be scalable in order to enable the target capacity to be reached and promote cost-effectiveness. Adherent cell …
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Being Thorough When Transferring Technology
…ogics?
Moscariello and Young (CMC Biologics): Depth filtration and centrifugation are not always scalable for manufacturing operations. However, having both technologies is desirable based on the…
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Downstream Processing for Cell-Based Therapies
…- and late-stage clinical development, significant focus has been directed toward the development of scalable, robust manufacturing processes. Much of the research and development activity in the sec…
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Enhancing Resins Addresses Purification Concerns
“The key challenge for any process developer working on a downstream process is to develop a robust, scalable, and cost-efficient process to get to market in a short time,” adds Ihre. For more mature …
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Gene Therapies Push Viral Vector Production
“Therefore,” Chaudhary explains, “the lack of scalable platform technologies for purification has proven to be a bottleneck in downstream processing. In addition, it is important to maintain AAV vecto…
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Platform Approach Speeds Process Development
A modular cell-culture platform demonstrates accelerated process development.
By Harald Bradl, Jan Bechmann, Benedikt Greulich, Markus Michael Mueller, Patrick Schulz, Thomas Wucherpfennig
C…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
However, ultracentrifugation is not easily scalable. We describe an evaluation of purification workflows from three different cell culture supernatants. The workflows we describe are suitable for scal…
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Genetic Vaccine Platforms Demonstrate Their Potential
…t allow the rapid development of a range of vaccines against emerging infectious diseases based on a scalable novel core technology platform. “The process to develop and produce genetic vaccines is h…
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Best Practices for Selecting a Top-Quality Cell Line
It is difficult to rapidly screen more cell types clones to enable the selection of scalable cell lines capable of generating better cell productivity and product quality that are stable over extended…