Search results for " scalable"
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
Science Focus Fuels Successful Process Development for Startups
Given the cost and time involved, being able to develop a practical and scalable process is essential to achieving success,” Sharei explains.
For Krystal Biotech, which is developing gene therapie…
Article
Case Study: Process for Production of Oncolytic Adenovirus
The case study describes a process from upstream cell culture to downstream purification, using scalable modern tools and technologies.
Read the case study on "Process for Production of Oncolytic…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
The biopharmaceutical industry continues to expand in new and exciting ways. What might be in store for 2019, and what important lessons should process developers take from 2018? Here, we look back …
Article
Scaling Up Novel Therapies
Chromatography and filter manufacturers have developed scalable and reproducible low-volume mimics of their industrial-scale equipment, which allow more accurate scale-up work than ever before, he say…
Article
A Plastic Pipeline for Commercial Bioprocessing?
“Some initial challenges involved proving that single-use manufacturing is scalable to commercial scale. There is enough evidence now that single-use technology is suitable for commercial-scale bioman…
Article
Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography
Early adopters are benefiting from lower costs and increased productivity.
By Cynthia A. Challener
Tashatuvango/Shu…
Article
Understanding Validation and Technical Transfer, Part I
The clinical formulations must be scalable to commercial production, retaining their effectiveness and safety attributes. Commercial production processes must be robust and reliable to ensure consiste…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
By Marcos Simon, Juan J. Giner-Casares
Cell…
Article
Going Small to Achieve Success on the Commercial Scale
…t achieved between the bench and commercial scales, and therefore, model processes are not perfectly scalable. The causes, according to Jorjorian, may not relate directly to the process, but can be a…