Search results for "antibody" in Articles / App Notes
Article
Tips for Successful Immunoprecipitation
For immunoprecipitation (IP), there are four main components that you can control to get good results: protocol, resin, format, and antibody. Read these tips to get it right from the start.
Ac…
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The New World of Biopharmaceutical Manufacturing
Companies are implementing end-to-end single-use platforms for monoclonal antibody, antibody drug conjugate, and vaccine production. Flexible facilities are likely to become an important part of large…
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Fusion Proteins Pose Manufacturability Challenges
…erent parts of the fusion protein, according to Paul Carter, senior director and staff scientist of antibody engineering at Genentech.
Combining two different proteins in one molecule can lead to…
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Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
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Improvements in Protein A Chromatography
Bolton recently published a paper “Role of more than 40 years of improvement in Protein A chromatography in the growth of the therapeutic antibody industry,” and also presented at the spring ACS meeti…
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Being Thorough When Transferring Technology
BioPharm: Are there specific challenges for the tech transfer of antibody-drug conjugates (ADCs)? Monoclonal antibodies? Cell therapies?
Moscariello and Young (CMC Biologics): The major challenges…
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Single-use Bioreactors Have Reached the Big Time
“Examples include traditional vaccines and blockbuster [monoclonal antibody] (mAb) biologics (>2 metric tons of mAb per year); in these cases, single-use bioreactors might not be the most efficient pr…
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High Throughput Protein Purification at a Glance
Within the Human Protein Atlas project, scientists are using ÄKTA systems to purify up to 180 protein samples per week. The project uses antibodies to study the localization of proteins in huma…
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Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…ing Manufacturing Technology
Continuous Processing for the Production of Biopharmaceuticals
Antibody Production in Microbial Hosts
Single-use Technologies in Downstream Process Intensific…
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Process Chromatography Selection for Downstream Processing Applications
Industry experts discuss best practices for selecting a separation technology.
By Caroline Hroncich
Process chromatography has changed significantly since it was first introduced to the biop…