Search results for " yield"
Article
Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
The goal was to separate BsAb monomer from fragments such as the individual heavy and light chain pairs while achieving high purity and yield of BsAb. MabSelect™ PrismA protein A resin was selected fo…
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Scaling Up Novel Therapies
For some cell therapies, the current process yield is only 30%, says Morris.
In internal testing, Pall scientists optimized process intensification to make 100 g/d of one product, enough…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
…am processing more flexible and cost-effective, but still generally not speedier or with much higher yields.
3) Manufacturing capacity, including commercial manufacturing, is in a “good place.” B…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
BioPlan has also reported data and trends for bioprocessing titers and yields over the past 30 or more years (5). Average commercial-scale titers have increased from estimated 1.1 g/L in 2003 to curre…
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Leveraging Data for Better Biopharmaceutical Process Control
We have developed a soft sensor applications for GMP biomanufacturing in which media components quality attributes are related to upstream yields or bulk product CQAs (e.g., stability) (4,5).
B…
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Preclinical Evaluation of Product Related Impurities and Variants
Recombinant GCSF processes can also yield other product-related species such as deamidated, N-terminal truncated, and norleucine forms of GCSF (14). The level of these species, however, is usually con…
Article
Process Chromatography Selection for Downstream Processing Applications
…rra-Arteaga (MilliporeSigma): It is challenging to compete with a technology able to provide >95% yield and purity with minimal process development required. However, there are mAb purification proce…
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Generating a Fully Processed Antibody
Finally, some multispecific antibody platforms require three or more chains/subunits to be expressed at ratios that give the highest yield and the required structure for these molecules to be active. …
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Managing Biomanufacturing Capacity Expectations
For example, concentrated fed-batch (CFB) cell culture has been shown in early experiments to yield products of similar quality compared with those made through traditional fed-batch culture (6). Not …
Article
Platform Approach Speeds Process Development
…e generation, cultivation media, and process design to increase the productivity and overall product yields in a biopharmaceutical process for the production of recombinant proteins.
At Boehringe…